Nutritional Pearls: Protecting Against Breast Cancer

Sarah is a 32-year-old woman who is concerned about her risk of developing breast cancer. At her most recent checkup, she asks if there are any simple lifestyle changes she could make that would help to lower her risk.

How do you advise your patient?
(Answer and discussion on next page)

Dr. Gourmet is the definitive health and nutrition web resource for both physicians and patients with evidence-based resources including special diets for Coumadin users, patients with GERD/acid reflux, celiac disease, type 2 diabetes, low sodium diets (1500 mg/d), and lactose intolerance. 

Timothy S. Harlan, MD, is a board-certified internist and professional chef who translates the Mediterranean diet for the American kitchen with familiar, healthy recipes. He is an assistant dean for clinical services, executive director of The Goldring Center for Culinary Medicine, associate professor of medicine at Tulane University in New Orleans, faculty chair of the all-new Certified Culinary Medicine Specialist program, and co-chair of the Cardiometabolic Risk Summit.

Now, for the first time, Dr. Gourmet is sharing nutritional pearls of wisdom with the Consultant360 audience. Sign up today to receive an update from the literature each week.

Answer: A few servings of fruit and vegetables each day could help to lessen the risk of breast cancer.

We've reported in more than one study that a Mediterranean-style diet appears to help prevent breast cancer, but it's not clear from existing research whether that is due to the overall dietary pattern or if it's likely to be the result of one or more of the 9 points of the Mediterranean Diet. As an example: A study that we've reported on focused on olive oil intake among those following a Mediterranean diet, but despite the positive results, the authors of that study noted that foods are not consumed in isolation, and that the results could be due to the participants' overall diet.

On the other hand, we have a pretty good idea of what contributes to your risk of breast cancer, including eating red meat, multivitamin use, and drinking alcohol. Why would there be so much more research into causes rather than prevention? You probably know it's easier to prove a positive than a negative.
________________________________________________________________________________________________________________________________________________________________________

RELATED CONTENT

Filling Up On Fruit Doesn't Improve Weight Loss
Eating Fruit Daily Reduces CV Risk by 40%
________________________________________________________________________________________________________________________________________________________________________

The Research

But that's not very helpful when you'd much rather avoid getting breast cancer. A team of researchers recently made use of data collected for the Nurses Health Study II—a large scale study of female nurses that began in 1989 and continues to this day—to look at whether fruits and vegetables might play a role in breast cancer prevention.¹ The study gathers its data through regular dietary questionnaires as well as the collection of information regarding the participants' health status and other information. In 1997, a portion of the women participating in the study filled out an additional dietary questionnaire about what they ate during adolescence (defined as the ages of 13 through 18). All told, this included nearly 45,000 women.

The Results

The authors grouped the women's intake of fruits and vegetables into 5 increasing levels, from "never or less than once per month" to "6 or more times per day." They also looked at specific fruits and vegetables, such as apples or kale. After taking into account an array of variables, including family history of breast cancer, alcohol intake during adolescence, fiber intake, red meat intake, body mass index, and whether they had children, the authors found that those women who reported consuming an average of 2.9 servings of fruit per day were 31% less likely to develop postmenopausal invasive breast cancer and 20% less likely to develop premenopausal breast cancer, with the possibility of breast cancer in general being 25% less likely. As it happens, just 1.4 servings of fruit per day yielded nearly the same risk reduction. According to the author's analysis, the amount of apples, bananas, and grapes the participants consumed during adolescence had the greatest power to reduce their risk of breast cancer.

Much higher levels of vegetable intake—4.5 servings per day—reduced women's risk of premenopausal breast cancer by only 16%, but their risk of postmenopausal breast cancer was cut by 25%. The most effective vegetables included yams or sweet potatoes, corn (which is really a whole grain), and kale, with green beans and peas being slightly less effective.

What’s the “Take-Home”?

I am a little concerned about this study. While the authors were quite careful to use validated food frequency questionnaires that appeared to have a fair amount of accuracy, the fact remains that the women participating in this recall were looking back on their adolescent diet from the age of 32, at best. At the age of 32, would you have remembered what you ate on a regular basis during high school? You might or might not recall with some accuracy, but it's definitely cause for concern.

That said, there's no question that fruits and vegetables are great for you, and it would appear from this study that eating an apple or banana at lunch and for snacks, with plenty of vegetables on sandwiches at lunch, may help prevent the development of breast cancer in the future.

Reference:

Reference:
Farvid MS, Chen WY, Michels KB, Cho E, Willett WC, Eliassen AH. Fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer: population based cohort study. BMJ. 2016;353:i2343.